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Chance Summary Neonates born to mothers using benzodiazepines late in pregnancy are already noted to encounter signs and symptoms of sedation and/or neonatal withdrawal [see Warnings and Precautions (five.8) and Clinical Concerns)]. Offered info from posted observational scientific tests of Expecting Gals exposed to benzodiazepines don't report a transparent association with benzodiazepines and major beginning defects (see Information).
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nine.3 Dependence XANAX may deliver physical dependence from continued therapy. Actual physical dependence is really a state that develops due to physiological adaptation in reaction to repeated drug use, manifested by withdrawal signs and signs and symptoms right after abrupt discontinuation or a big dose reduction of a drug. Abrupt discontinuation or speedy dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, may possibly precipitate acute withdrawal reactions, like seizures, which may be existence-threatening.
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The benzodiazepines comprise a primary benzene ring that may be connected using a 7-membered diazepine ring, getting two nitrogen constituents Positioned at R1 and R4. Chemically, it's got exactly the same construction, as an alternative to in the R1 situation, it can be changed having a methyl group.
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